HRE is a three-letter abbreviation which may represent any of the following:

• Harare International Airport (IATA airport code: HRE)
• Holy Roman Empire
• Holy Roman Emperor
• Hormone response element
• Hre (also spelled Hrê or H're), an ethnic minority and language of Vietnam
• HRE, a level of the hardness of metallic materials on the Rockwell scale
• Human rights education

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