Interstate 210 is the designation for several Interstate Highways in the United States, all of which are related to Interstate 10:

• Interstate 210 (California), or the Foothill Freeway, a major east-west freeway running through the heart of the greater Los Angeles area.
• Interstate 210 (Louisiana), a bypass route in Lake Charles, Louisiana.

The following roads used to be numbered I-210:

• Interstate 165 in Mobile, Alabama.

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